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One of the physiological substrates of this transporter is acetylcholine, underlying a key role in the non-neuronal cholinergic system in both physiological and pathological conditions, as testified by the occurrence of a natural mutation of OCTN1 in inflammatory conditions such as Crohns Disease (Pochini et al., 2019)

This obesity-induced chronic inflammation plays an endorsing role in cancer progression due to its promotion of a permissive microenvironment for neoplastic transformation (5)

Elian V et al