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Journal of Applied Physiology, 97, 147785

When your metabolism is functioning correctly, your body is better at burning fat and regulating hunger naturally

IGF-1 availability is tightly regulated by the so-called insulin-like growth factor binding proteins (IGFBPs), which may act by increasing IGF-1 half-life, from minutes to hours (most commonly by forming a tertiary complex with Acid-Labile Subunit and IGFBP3), however blocking its binding to the insulin-like growth factor 1 receptor (IGF-1R) [9395]

This minimal difference between year one and year two confirms that the medication maintains weight loss over extended treatment without significant regain