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This type of big data research will generate lots of statistical associations, some of which will be spurious
In the early stages of AD, ferroptosis may act as a co-trigger of A aggregation and tau hyperphosphorylation by promoting neuronal degeneration, driving microglial polarization, and compromising the integrity of the bloodbrain barrier (BBB)
Annals of Internal Medicine, 178 (9), 12681278
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