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A phase 3 trial called REDEFINE-1 included over 3,400 people who were overweight or obese with one or more comorbidities (like hypertension or cardiovascular disease), but not type 2 diabetes
Highly specific epigenome editing by CRISPRCas9 repressors for silencing of distal regulatory elements
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Yes, that's the historical origin
there was a drop of B12 on the end of the needle, maybe that's another reason too
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