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5 Through topical application of hydroquinone, there is reversible depigmentation of the skin via inhibition of tyrosinase which normally converts tyrosine to 3,4-dihydroxypheylalanine (dopa)

Fractionation of this sleep-promoting blood eventually yielded a small nine-amino acid peptide that could reproduce these effects, and Monnier and colleagues published their findings in 1977, entering the compound into the scientific literature as Delta Sleep-Inducing Peptide

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