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The researchers found that when participants took semaglutide, they saw the following improvements: 42 percent lower risk of psychiatric-related hospital care and sick leave 44 percent lower risk of worsening or new depression 38 percent lower risk of worsening or new anxiety 47 percent lower risk of substance use disorder diagnosis or treatment Other GLP-1 drugs showed more variable effects: Liraglutide was linked to a lower risk of worsening depression but not anxiety
2022 Feb 5;14(1):23
It also plays a role in energy homeostasis and cellular metabolism
Third, step therapy requirements may apply
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