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Further confidence in the assay design came from testing the effects of BETP on receptor-mediated Arr signaling

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Furthermore, in a 12-week RCT in which patients were either assigned to liraglutide (1.8 mg/day), sitagliptin (100 mg/day) or placebo, no difference in glycemic control or bodyweight reductions were found, and both treatments failed to reduce liver hepatic fat content compared to placebo (69)

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However, due to the limited number of countries in which studies have been performed, exact interpretation of this issue must be with precaution

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