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Once STAT3 is recruited and phosphorylated by JAK2, it forms dimers that translocate to the nucleus where they act as transcription factors
It is a natural hormone produced in your own body
Key symptoms include severe flank or lower back pain radiating to the groin, blood in urine, increased urinary frequency or urgency, and nausea with vomiting
This mechanistic depth is the basis for Phase 2 outcomes that exceeded all prior single- or dual-agonist research
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