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4 Studies indicate that NAION occurs in up to 1 in 10,000 patients
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40,105 However, given that IGF-1R and insulin receptor have decreased affinity for each others main ligand in comparison to their main ligand, it is likely that insulin and IGF-1 cannot stimulate the anabolic effects of each others receptor activation to the same degree as the main ligands for insulin receptor and IGF-1R at physiological concentrations
Retrieved Dec 20, 2023, from Avgerinos KI, Spyrou N, Bougioukas KI, Kapogiannis D
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