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(March 2023)
Research has focused on three primary domains related to ferroptosis in OA: iron homeostasis, lipid metabolism, and the antioxidant defense mechanism
These incretin effects explain the initially surprising weight loss observed in the treatment groups of the cardiovascular trials, with subjects taking GLP-1/GIP agonists losing from 3% to 12% of their body weight
Cardiovascular side effects with semaglutide are generally mild, and the SELECT trial demonstrated a 20% reduction in major adverse cardiovascular events (MACE) in people with established heart disease
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