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CJC-1295 with DAC binds GHRH-R on somatotrophs and provides sustained GHRH-axis stimulation across days, but it depends on endogenous ghrelin tone for GHS-R1a input
Any noticed abnormalities should be investigated accordingly
Although rates of acute pancreatitis have been low and similar between GLP-1 agonists and placebo in studies, caution is still warranted since acute pancreatitis carries a risk of recurrencewhich can turn into chronic pancreatitiswhich can increase risk of pancreatic cancer
