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Indications and uses MOUNJARO is indicated as an adjunct to diet and exercise to improve glycemic control in adults and pediatric patients 10 years of age and older with type 2 diabetes mellitus

Phase IIa trial of ASC30, a once-monthly GLP-1 agonist for obesity Novo Nordisk's oral semaglutide (Rybelsus) has become the first FDA-approved oral GLP-1 therapy to reduce major cardiovascular events in high-risk type 2 diabetes patients Clearmind Medicine filed a U.S

Skin reactions may result from: Immune-mediated hypersensitivity to the active semaglutide molecule itself Reactions to pharmaceutical excipients , particularly phenol or other preservatives Local tissue irritation from the subcutaneous injection process Formation of anti-drug antibodies , though this occurs in fewer than 1% of patients according to the EMA European Public Assessment Report (EPAR) for Ozempic Factors that may potentially increase susceptibility to Ozempic skin reactions include: Previous allergic reactions to other GLP-1 receptor agonists (such as liraglutide or dulaglutide) History of atopic conditions although evidence specifically linking atopy to increased risk of semaglutide reactions is limited Multiple drug allergies or known hypersensitivity to injectable medications Improper injection technique , such as injecting too superficially or failing to rotate injection sites Concurrent skin conditions at the injection site To minimise injection site reactions, avoid injecting into areas of infection, lipodystrophy, scars or active dermatitis