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March 16, 2023 AMA #45: Pros And Cons Of GLP-1 Weight Loss Drugs And Metformin As Geroprotective Agent | The Drive with Peter Attia #246 Check out The Drive episode page Key Takeaways GLP-1 and GIP both started as drugs to control glucose and insulin resistance in people developing or with type 2 diabetes Studies showed the added benefit of GLP-1 agonists on weight loss but the mechanism is unclear, though they do reduce appetite in some way Introduction In this special episode of The Drive, Peter focuses the discussion on two topics getting a lot of attention recently: GLP-1 agonists for weight loss and metformin for longevity
5c and Extended Data Fig
9 During pathological states, reaction between nitric oxide and superoxide can generate highly reactive peroxynitrite (ONOO-) radicals, which are implicated in lipid peroxidation
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