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Medications that reduce absorption of B12 metformin (for diabetes) and antacids (that reduce the amount of stomach acid) are the main ones
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NNMT is over-expressed in fat and liver tissue in obese, diabetic animals, and genetic knockdown of NNMT protects mice against diet-induced obesity by increasing energy expenditure
[3] Treatment is by vitamin B 12 supplementation, either by mouth or by injection
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