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While animal safety data is extensive and positive, no clinical safety data in humans has been published
Cytosolic and mitochondrial pools are functionally compartmentalized, and exchange between these domains occurs indirectly through metabolite shuttles [110]
References: Babu MM, Luscombe NM, Aravind L, Gerstein M, Teichmann SA
Short communication: TNF- and IGF-1 regulates epigenetic mechanisms of HDAC2 and HDAC10 [PMID: 35143520] Laboratory literature summary: Short communication: TNF- and IGF-1 regulates epigenetic mechanisms of HDAC2 and HDAC10
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