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BBB dysfunction in these pathologies may result in compromised transport and permeability properties of the barrier as well as in alterations in cerebrovascular regulatory mechanisms of blood flow, with ensuing perturbed signalling between brain endothelium and associated cells, such as glia and neurons

This decrease in food consumption can result in insufficient energy, contributing to feelings of fatigue

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[273] For example, during the early 1970s in the United States, amphetamine became a schedule II controlled substance under the Controlled Substances Act