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Antioxidants may help with anti-aging
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The validity of the in vivo data presented here is reinforced by our observations of concomitant increases in sustained over acute plasma insulin levels from beta cell -arrestin 2 KO versus control mice, as well as by the loss of effect when using exendin-phe1, an exendin-4-derived GLP-1RA with a single amino acid N-terminal substitution biased away from -arrestin recruitment (Jones et al., 2018), a feature that likely allows it to bypass both the positive and the negative effects of -arrestin 2 for its in vivo responses
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