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[99] In contrast to generics, which may be chemically synthesized versions manufactured using different processes than the original biologic drug, Health Canada confirmed that Plosbrio and Poviztra differ from the existing proprietary drugs Ozempic and Wegovy only in name and packaging, and are unrelated to the generics from a regulatory perspective

Note that semaglutide and tirzepatide typically have different standard dosing levels, which is handled in the regression model by the drugType:dose interaction term

Yang F, Kemp CJ, Henikoff S