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Common adverse effects include nausea (reported in 20-44% of patients), vomiting, diarrhea, constipation, and abdominal discomfort
The primary outcomes measured were the change in the KCCQ-CSS and the percentage change in body weight from baseline to week 52
1,4,5 A network meta-analysis of randomised controlled trials comparing the effects of anti-hyperglycaemic medications on muscle mass in people with T2D revealed that 40% of the weight lost through GLP-1 medications (Semaglutide) is fat free mass including skeletal muscle
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