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So far, semaglutide (Wegovy) shows the most significant weight loss among approved GLP-1s: Average weight loss: 15 percent or more of body weight over time Administered once weekly Tirzepatide (Mounjaro), though not a pure GLP-1, has shown even greater weight loss in trials and was approved by the FDA specifically for weight management under the name Zepbound
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Some trials have reported improvements in power output and aerobic capacity, whereas others have found no significant effect
For any serious researcher, understanding this distinction isn't just helpfulit's absolutely critical for designing valid, targeted, and reproducible studies
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