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Previous studies from our group and others have shown that HO concentrations of 50100 M can induce glial reactivity and cytotoxicity in primary retinal cultures, with higher concentrations eliciting amplified neuroinflammatory responses [30, 38]
doi: 10.3389/fcell.2021.671247 162 WuDDongSZhouW
however, this theory has been called into question as APAP-protein adducts have been detected at 1 hour after APAP treatment, a time that that would precede GSH depletion
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