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Non-systemic HRT has minimal systemic absorption, and comes in these forms: vaginal creams vaginal rings vaginal suppositories Systemic HRT This type of HRT enters your bloodstream and circulates to different organs and tissues in your body, comes in the form of: pills patches topical gels and sprays pellets (which Midi doesnt recommend) As for combinations, systemic HRT can include estrogen, progesterone (or progestin, which is synthetic progesterone), or a combo of the two: Combined estrogen and progesterone therapy This is the most common form of HRT, typically prescribed to women who still have their uterus
Chen W, Guo C, Huang S, Jia Z, Wang J, Zhong J, et al