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Similarly, the American Association of Clinical Endocrinology introduced its Adiposity-Based Chronic Disease model, replacing BMI-centric classification with a staging system based on obesity-related complications [4]
Given the medications superior metabolic effects, researchers anticipate at least equivalent cardiovascular benefits, but confirmation awaits trial completion
Another GLP-1 analogue, lixisenatide, was reported to prevent the acuteness of cardiovascular events in apolipoprotein E / insulin receptor substrate 2 +/ (APOE / irs2 +/ ) mice by reducing the size of AS plaques, increasing plaque stability, and promoting the conversion of macrophages to the anti-inflammatory M2 phenotype (129)
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