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The regulatory answer is more layered than a simple yes or no, and it shifted in 2026
The NTS receives input from cardiac and vascular chemoreceptors and mechanoreceptors, as well as pulmonary and central pathways, and relays this information to respiratory centres such as the pre- Btzinger complex, considered a key respiratory rhythm generator, as well as to the parabrachial nucleus, and locus coeruleus , thereby promoting physiological coordinated cardiovascular and respiratory function
Bone morphogenetic protein 9 is a paracrine factor controlling liver sinusoidal endothelial cell fenestration and protecting against hepatic fibrosis
These areas have relatively thick skin with good barrier function
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