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A small but growing body of evidence has explored this question: Castaeda et al., 2025 ( Lancet Obstetrics, Gynaecology & Womens Health ) Postmenopausal women treated with tirzepatide who were also using menopausal hormone therapy lost approximately 35% more weight than non-users

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This study also highlights the use of molecular docking and molecular dynamics simulations for screening selective inhibitors of human 3-MST