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PubMed: 18436195Clinical (RCT / meta-analysis) ref-8.Shahbazian H, Shayanpour S, Ghorbani A Evaluation of administration of oral N-acetylcysteine to reduce oxidative stress in chronic hemodialysis patients: A double-blind, randomized, controlled clinical trial
Preclinical findings indicate that the peptide supports structural and functional preservation in a wide range of tissues, including the upper and lower gastrointestinal tract, hepatic and pancreatic tissue, skeletal muscle, ocular structures, cardiac tissue, and neural systems
In chloroplasts, the role of ascorbate has been proposed during breakdown of water in thylakoid lumen while in stroma to detoxify H 2 O 2 formed by the action of Fe-SOD and Cu/Zn-SOD (Gallie, Role of ascorbate in chloroplast redox reactions The biosynthesis of this vital metabolite (ascorbate) takes place in mitochondria, however, its prime requirement is in the chloroplast (Foyer, Arabidopsis thaliana , and it belongs to phosphate transporter 4 family, AtPHT4.4 (Miyaji et al., 2015)
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