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Contrave may modestly increase blood pressure/heart rate Contrave has more contraindications, including seizure disorders, eating disorders, and opioid use Neither is a controlled substance, unlike phentermine Contrave costs less ($100-300/month vs $199-349/month for semaglutide) Both are FDA-approved for weight loss, though through different formulations How Each Medication Works Understanding the mechanisms explains why these medications produce different effects and suit different patients
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Mild systemic symptoms such as headaches, flushing, fatigue, or nausea typically resolve within one to two weeks as the body adapts
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