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The unfortunate truth is that big risk signals (lets say the kind you get from drinking antifreeze) can be spotted from the anecdotal experience of people in the world just trying things, but small-but-serious risk signals (lets say cardiovascular disease with tofacitinib) are really hard to identify without a proper trial or a proper observational study

[5] Chan, Y

Expand Patient Access: Addressing affordability and improving healthcare access, particularly in emerging markets like India and China, will be key to market penetration

Normal variations that do not require concern A week with no weight loss after several weeks of consistent loss is completely normal