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Large doses of canthaxanthin may have unpleasant side effects and can cause serious health issues, according to the hives and welts liver damage canthaxanthin retinopathy, a condition where crystals form in the retina of the eye stomach cramps and diarrhea nausea aplastic anemia, where the body stops producing enough new blood cells Some of these side effects may disappear as soon as a person stops taking the pills

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Public Health England, NHS England and NICE have not been able to provide any clinical evidence either