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Abstract Dipeptidyl peptidase-4 (DPP-4), also known as the T-cell antigen CD26, is a multi-functional protein which, besides its catalytic activity, also functions as a binding protein and a ligand for a variety of extracellular molecules

However, efficacy in clinical studies has been disappointing, possibly because excessive chronic stimulation is associated with receptor internalisation, and some agents have disturbed liver function [25, 26]

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Thats why many people find this approach helps them stay on track and is easy to stick with long term