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Achieving site-specific transcranial drug delivery to closed-skull TBI patients may be more difficult than the authors imply: the subarachnoid space filled with circulating cerebrospinal fluid (CSF) is about 3-4 mm deep in humans (3), more than an order of magnitude deeper than in mice, permitting CSF to quickly remove drug molecules from a targeted cortical site
Garvey WT, Frias JP, Jastreboff AM, le Roux CW, Sattar N, Aizenberg D, Mao H, Zhang S, Ahmad NN, Bunck MC, Benabbad I, Zhang XM, Abalos FH, Manghi FCP, Zaidman CJ, Vico ML, Aizenberg D, Costanzo PR, Serra LP,
DrachlerJCPolandFet al
Although not thought to be directly influenced by obesity, lipoprotein (a) is an independent risk factor for cardiovascular disease that is determined by genetics
