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International Immunopharmacology , vol
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Phase 2 clinical trial data published in 2023 in the New England Journal of Medicine (Jastreboff et al., NEJM 2023) demonstrated that retatrutide produced substantial reductions in body weight up to approximately 24% over 48 weeks at the highest dose studied (12 mg once weekly) in adults with obesity alongside meaningful improvements in glycaemic control and cardiometabolic markers
GLP-1 stimulates insulin secretion, inhibits glucagon secretion at pancreatic cells and has also extrapancreatic influences as slowing of gastric emptying which increases the feeling of satiety
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