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For example, if a certain substance is known to greatly slow down one of these enzymes, then any drug broken down by that enzyme will be present in the bloodstream in far higher amounts, leading to overdose

Chemotherapy with drugs like 5-fluorouracil has also been associated with acute thiamine deficiency by disrupting thiamine activation, so oncology patients receiving such therapy might receive parenteral thiamine supplementation as part of this B-Complex if needed

Various measures can complement each other thereby improving the predictive power of the composite measure

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