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In 2000, a research study was carried out in obese Zucker rats where the AOD 9604 peptide was given daily for 19 consecutive days

Pickart stated that GHK-Cu has a favorable safety profile, highlighting that there is no indication that it causes side effects in test subjects [2]: The molecule is very safe and no issues have ever arisen during its use as a skin cosmetic or in human wound healing studies. In a 2018 review based on new genetic data, he reiterated that all biological actions associated with GHK appear to be health positive. He pointed to over four decades of GHK research encompassing cell, tissue, and animal studies, also noting the peptides inclusion in commercial anti-aging and cosmetic products such as creams, liposomes, and dermal patches [1]

Some individuals may experience digestive upset or nausea, especially if taken on an empty stomach

Furthermore, Lico E also restored arginase 1 expression, supporting its neuroprotective role