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11 Whole brain cFos expression in response to semaglutide, MK-801, GLP-1 and GLP-1MK-801
An additional mode of communication from the gut to the brain includes the enteric nervous system (ENS) and sensory neurons expressing receptors to TNF-, IL-1 or IL-6 (243), and to 5-HT (244), which is abundantly produced at the gut level (245) (upwards black arrows in Figure 2 )
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In the U.S., the Centers for Disease Control and Prevention reports more than 100 million adults, or about 42 percent of the population, are living with obesity, accounting for $173 billion in medical expenditures
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