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As of April 22, 2026, it was removed from FDA Category 2, but the FDA's Pharmacy Compounding Advisory Committee will not consider it for the 503A bulks list until the July 23, 2026 meeting

doi: 10.3389/fnagi.2025.1617106 Received 23 April 2025 Accepted 30 June 2025 Published 18 September 2025 Volume 17 - 2025 Edited by Francisco Navarrete, Miguel Hernndez University of Elche, Spain Reviewed by Robert Fekete, New York Medical College, United States Yutaka Oji, Juntendo University, Japan Updates Copyright 2025 Chaudhary, Chaudhary and Rawat

Combining them creates a multi-pathway approach that helps improve the look of existing discoloration and prevents new dark spots from forming

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