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not recommended for use with DPP-4 inhibitors Common side effects : Gastrointestinal symptoms (nausea, vomiting, diarrhea) that typically diminish with continued use and proper dose titration Referral to endocrinology or obesity medicine specialists is appropriate for complex cases, including patients with multiple failed therapies, significant comorbidities, or those requiring comprehensive weight management programs

In the OASIS 4 clinical trial, adults taking the 25mg Wegovy tablet lost an average of 13.6% of their body weight over 64 weeks, compared with 2.2% for those taking a placebo

The detailed subgroup analysis of different GLP-1 RA groups compared to non-GLP-1 RA users is demonstrated in Table 4