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Ferrous iron is released into the cytosol from ruptured lysosomes following exposure to a hazardous dose of APAP, which induces the production of reactive oxygen species in what is called the Fenton reaction
Other spirochete infections that have been associated with a Herxheimer reaction include syphilis and leptospirosis
This is similar to the primary pathway which starts from glucose however this pathway branch off from GDP-D-mannose
J Neurochem 2006
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