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The study found that the effect of melatonin was not due to the melatonin receptors but rather acts in a receptor-independent manner to clear amyloid-beta plaque.[ref] In addition to clearing amyloid-beta plaque, another way that melatonin can protect against Alzheimers is through the reduction of ROS in the mitochondria in brain cells.[ref] This may be the key, rather than amyloid-beta clearance
That said, the favorable safety profile in trials suggests AOD 9604 does not pose age-specific risks
In its epithalon review, the International Peptide Society covered Professor Khavinsons work on epithalon peptide and its anti-aging effects, and has published two epithalon dosing protocols based on their findings [15]