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In preclinical models, such as methionine-choline deficient dietary models, liraglutide reduced hepatic inflammation by decreasing the infiltration of M1 pro-inflammatory macrophages and attenuated early fibrotic changes, effects that occurred independently of weight loss

238 Despite these gains, it has also been suggested that whereas conjugation shields targeting peptides from proteolysis to some extent, altering the peptide sequence to increase protease resistance can significantly increase homing and transport efficiency