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Because of its ability to promote weight loss and improve blood sugar management, semaglutide has become an important treatment for both diabetes and obesity

Septerna has developed a native complex platform that can reconstitute the GLP-1 receptor within an artificial lipid bilayer, complexed with combinations of drug and internal cell signalling molecules, which replicates the dynamics of the signalling process at scale

Disclosures: Researchers reported relationships with Eli Lilly, Apollo Therapeutics, Elsevier, Novo Nordisk, Roche, Bayer, Antag Therapeutics, Boehringer Ingelheim, Carmot, Diasome, Gentibio, Rhythm, and vTv Therapeutics outside the submitted work

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