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Statements Author contributions CX and YC conceptualized the manuscript
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IGF-I/IGF-IR signaling in chondrogenesis Although the above global KO mice confirmed the importance of IGF-I/IGF-IR signaling in supporting skeletal development, they did not specify the action of IGF-I signaling in specific cell lineages in the bone or exclude the impact of other systemic derangements on the skeleton
Fluorescence signals from samples were then measured on a microplate reader at Ex/Em = 535/587 nm
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