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Another proposed mechanism involves impulse control and decision-making
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2024 NEJM) actually showed a slower decline in eGFR over time on semaglutide in people with CKD and type 2 diabetes, a 24 percent relative reduction in kidney failure and cardiovascular death
Conversely, those with variants associated with lower GLP-1 pathway engagement may be candidates for combination evaluationbut only after comprehensive cardiovascular clearance
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