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Here, we provide the first evidence of improved healthspan and age-related survival with a therapeutic mAb by demonstrating that treatment with an IGF-1R antagonist in older mice significantly and preferentially improves several indices of healthspan, reduced death from neoplastic disease, and increased mean and median lifespan in females

We investigated two common TYMS polymorphisms in 94 MDS and 113 control mothers of Italian origin (Copped et al., 2009), namely a 28-bp short tandem repeats (rs34743033) in the 5-untranslated region (5-UTR) that is linked to gene expression levels (Horie et al., 1995), and a 6-bp deletion (1494 ins/del) polymorphism in the 3-UTR (rs34489327) that affects mRNA stability into the cytoplasm (Ulrich et al., 2002)

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