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Lactate in the brain: from metabolic end-product to signalling molecule
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Erythrocyte-derived microvesicles have been shown to induce blood clotting through activation of Hageman factor (factor XII) [51]
Notably, LASSS displayed additional functions to promote receptor binding-affinity and nitration resistance of HGF in a dose-dependent manner, that is high-dose LASSS in excess of a 1:4000 molar ratio to HGF, as revealed by biochemical assays after wash-out of un-reacted free LASSS (Figure 2a-d)
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