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Additional nutrients like curcumin, N-acetylcysteine, selenium , and vitamins C and E may support glutathione production and enhance results

Some outcomes did not reach statistical significance in all populations, highlighting the need for further high-quality clinical research

This can be mechanical (physical blockage) or functional (impaired motility)

Why this matters for drug discovery Editor's note: Updated July 27, 2026 with the published evoke and evoke+ biomarker data from The Lancet, including neurofilament light and GFAP results that point in conflicting directions