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We identified Y211 as another residue of interest as it forms part of the carnitine binding site and is one residue downstream Na + -coordinating N210 on TM4

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"The core finding of our work is that the natural compound KQS-1 can effectively "re-educate" these dysfunctional Tregs," Yang says, adding that "this strategy offers a promising and novel therapeutic avenue for the treatment of allergic asthma and potentially other immune-mediated diseases characterized by Treg dysfunction." Source: Journal reference: Sun, X., et al

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