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Another GLP-1 analogue, lixisenatide, was reported to prevent the acuteness of cardiovascular events in apolipoprotein E / insulin receptor substrate 2 +/ (APOE / irs2 +/ ) mice by reducing the size of AS plaques, increasing plaque stability, and promoting the conversion of macrophages to the anti-inflammatory M2 phenotype (129)

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Furthermore, compared with the HCD group, the HCD + ALC group showed significantly decreased Srebp2 , Hmgcr , Ldlr , Apob , and Abcg8 mRNA levels and a significantly increased Abcg5 mRNA level (Figure 3H)