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Methylfolate is required in the activation of tetrahydrobiopterin (i.e., BH4), which is a necessary cofactor for both tryptophan hydroxylase and tyrosine hydroxylase, enzymes required in the synthesis of serotonin and norepinephrine/dopamine, respectively (Figure 1)

These effects were considered secondary to the pharmacological effects of tirzepatide on food consumption and body weight

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Moreover, folate is critical for pregnant women to reduce the risk of birth defects.* CARDIOVASCULAR SYSTEM HEALTH* CAN REDUCE RISK OF BIRTH DEFECTS*^ ^Women who consume healthful diets with adequate folate throughout their childbearing years may reduce their risk of having a child with a birth defect of the brain or spinal cord