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Schafer and Buettner (Free Radical Biology and Medicine, 2001) formalised the GSSG/2GSH couple as a quantitative index of the cellular redox environment, a framework still used to describe redox state across proliferation, differentiation and apoptosis in cultured cells
Does Glutathione decrease as we age
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Accordingly, recent findings using dynamic oxidant recovery assays and GSH-specific fluorescent reporters, established that free communication of GSH pools exists between cytosol and IMS
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